7:00 AM to 9:00 AM Concurrent Session 1
Lahaina 1 and 2
Neuronal Circuit Mechanisms Underlying Complementary Facets of Social Behaviours, Chair: Manuel Mameli, The University of Lausanne
Neural Representation of Group Sociality and Communication in Bats,
Michael Yartsev, University of California, Berkeley
Neural Circuit Mechanisms of Social Reward,
Scott Russo, Icahn School of Medicine At Mount Sinai
An Habenular Circuit for Parental Behaviours,
Manuel Mameli, The University of Lausanne
7:00 AM – 9:00 AM Concurrent Session 2
Lahaina 3 and 4
Poster Talks
Chair: Tracey Petryshen, Concert Pharmaceuticals
Alterations in the Expression of CircRNAs Derived from Schizophrenia GWAS Loci in iPSC-Derived Neuronal Cultures of Patients With Early Onset Schizophrenia,
William Wylie, University of New Mexico Health Science Center
Defining the Global Protein Interaction Landscape of High Confidence Autism Spectrum Disorder Risk Genes,
Zun Zar Chi Naing, University of California, San Francisco
Relating Interindividual Differences in Cerebral Organoids to Longitudinal Infant Brain Growth,
Madison Glass, University of North Carolina at Chapel Hill
Inducible Calling Cards: Developing Mouse Reagents for Temporally Controlled Recording of Molecular States and Neural Activity,
Simona Sarafinovska, Washington University in St. Louis
Investigating Microglial Remodeling of Synapses in Major Depressive Disorder-Associated Suicide Death,
Elisa Gonçalves de Andrade, University of Victoria
Mitochondrial DNA Variants Associated With Bulimia Nervosa,
Ana Silva, Centre for Addiction and Mental Health
Modeling PTSD Differential Gene Expression in iPSC Derived Neural Cultures Treated With Glucocorticoids,
Cameron Pernia, Harvard Medical School, McLean Hospital
Detection of Autism Spectrum Disorder-Related Pathogenic Variants by a Novel Structure-Based Approach,
Sadhna Rao, University of Southern California
Searching for Schizophrenia Biology: Overlap Analysis of Cell Type-Specific Phenotypes in CNV Mouse Models,
Hayley French, Karolinska Institutet
Striatal Thalamic Resting-State Network Dysconnectivity in Youth With 22q11.2 Deletion Syndrome,
Charles Schleifer, David Geffen School of Medicine at UCLA
The Effects of Genetic Polymorphisms in Dopamine Signaling on Prefrontal Functional Connectivity and Working Memory Performance,
Rye Young Kim, Ewha W. University
9:00 AM to 9:15 AM Break
9:15 AM to 11:15 AM Concurrent Session 1
Lahaina 1 and 2
The Case for Deep Phenotyping in Psychiatric Genetics: Insights from Rare CNVS in Neurodevelopment, Chair: Carrie Bearden, UCLA; Co-Chair: David Glahn, Harvard Medical School/Boston Children’s Hospital
Rate of Deleterious Copy Number Variants Similar in Early Onset Psychosis and Autism Spectrum Disorders: Implications for Clinical Practice,
David Glahn, Harvard Medical School/Boston Children’s Hospital
Prioritizing Genes Driving Neuroanatomic Features in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics,
Gil Hoftman, Semel Institute for Neuroscience and Human Behavior at UCLA
Deep Phenotyping of the Schizophrenia-Associated 3q29 Deletion Exposes the Cerebellum as a Central Point of Vulnerability,
Jennifer Mulle, Robert Wood Johnson Medical School
Phenotyping Across CNVs, Genes, and Exons in Autism,
Stephan Sanders, UCSF
9:15 AM – 11:15 AM Concurrent Session 2
Lahaina 3 and 4
Natural Sleep Regulation and Psychiatric and Neurologic Diseases Characterized by Dysregulated Sleep: Hanna M. Ollila, Chair and Jacqueline Lane, Co-Chair
A Novel Target to Modulate Wakefulness and Cognition – The Neurosteroid Approach, Martin Schalling, Karolinska Institutet
Sleep Control Across Lifespan, Shibin Li, Stanford University
Shared Genetic Underpinnings of Sleep and Psychiatric Disorders, Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT
USF Transcription Factors Regulate Sleep and Circadian Rhythms, Nasa Sinnott-Armstrong, Stanford University
11:15 AM – 11:30 AM Break
11:30 AM – 12:30 PM The Tianqiao and Chrissy Chen Plenary
Lahaina 1 and 2
A Molecular- Neural Circuitry Substrate for Cognitive Dysfunction in Schizophrenia, David Lewis, University of Pittsburgh
12:30 PM – 5:00 PM Mid-Day Break
5:00 PM – 7:00 PM Concurrent Session 1
Lahaina 1 and 2
Emerging Intersectional Technologies for Probing Molecular Mechanisms of Neurotransmitter Co-Transmission in Brain and Behavior, Chair: Zachary Freyberg, University of Pittsburgh
Intersectional Genetic Approaches to Dissecting Roles of Dopamine/Glutamate Co-Transmission in Cell Resilience,
Zachary Freyberg, University of Pittsburgh
Intersectional Genetic Tools Reveal Cell-Type Specific Transcriptional Networks of Co-Transmitting Glutamatergic and Dopaminergic Neurons,
Ryan Logan, Boston University School of Medicine
INTRSECT: Precise Virus-Based Molecular Tool Expression in Multiply-Defined Neuron Subpopulations,
Lief Fenno, Stanford University
Diverse Functions of VTA Neurons Defined by Multiple Genetic Characteristics,
David Root, The University of Colorado Boulder
5:00 PM – 7:00 PM Concurrent Session 2
Lahaina 3 and 4
Modeling Neurodevelopmental Disorders Using Human Pluripotent Stem Cells, Chair: Sundari Chetty, Stanford University
Alterations in Neuronal physiology, Development and Function Associated with a Common Duplication of Chromosome 15 Involving CHRNA7,
Kristen Kroll, Washington University School of Medicine
Human Neuronal Activity-Dependent Gene Programs Enriched for Autism Heritability,
Gabriella Boulting, Neurobiology, UMass Chan Medical School
Modeling Brain Overgrowth in Autism Using Human Pluripotent Stem Cells,
Sundari Chetty, Stanford University
7:00 AM – 9:00 AM Poster Session with Breakfast
Maui Suites 1-3
9:00 AM – 9:15 AM Break
9:15 AM – 11:15 AM Concurrent Session 1
Lahaina 1 and 2
The Role of Astrocytes in Neurodevelopmental and Psychiatric Disorders, Chair: Zila Martinez-Lozada, The Children’s Hospital of Philadelphia
BDNF Signaling onto Astrocyte TrkB.T1 Drives Astrocyte Structural Plasticity and Supports Glutamatergic Synaptogenesis,
Michelle Olsen, Virginia Tech, School of Neuroscience
Neurons and Endothelial Cells Regulate Astrocyte Transcriptome,
Zila Martinez-Lozada, The Children’s Hospital of Philadelphia
Role of Astrocytes in Environment-Environment interaction: Focus on Dopaminergic Neurotransmission in the Striatum,
Kateryna Murlanova, SUNY-UB
Astrocyte-Autonomous WNT/beta-Catenin Signaling Regulates Synapse Maturation and Social Behavior,
Anna Victoria Molofsky, University of California San Francisco
9:15 AM – 11:15 AM Concurrent Session 2
Lahaina 3 and 4
Linking Mental Health and Physical Health Using Genetics, Functional Genomics, and Large Scale Electronic Health Record Data, Chair: Kritika Singh, Vanderbilt University Medical Center
Investigating the Shared Functional Biology of Coronary Artery Disease and Depression,
Kritika Singh, Vanderbilt University Medical Center
Investigating the Psychiatric Comorbidities of Endometriosis from Genetic and Phenotypic Perspectives,
Dora Koller, Yale University School of Medicine
Exploring the Clinical Associations and Genetic Etiology of Adult Weight Trajectories Using Electronic Health Records,
Jiayi Xu, Ichan School of Medicine at Mount Sinai
Genome-Wide Association Study of Problematic Opioid Prescription Use in 132,113 23andMe European Research Participants,
Sandra Sanchez-Roige, University of California, San Diego
11:15 AM – 4:00 PM Mid-Day Break
4:00 PM – 6:00 PM Concurrent Session 1
Lahaina 1 and 2
New Technologies and Novel Insights for Dissecting Dopaminergic and Serotonergic Circuits, Chair: Stephan Lammel, UC Berkeley
Dopamine Firing and Release in a Heterogenous Mesoaccumbal Dopamine System,
Stephan Lammel, UC Berkeley
All Optical Investigation of Synaptic Connectivity in the Intact Brain,
Hillel Adesnik, UC Berkeley
Imaging Serotonin and Psychedelic With Genetically Encoded Indicators,
Lin Tian, University of California, Davis
Behavioral and Dopaminergic Signatures of Resilience,
Lindsay Willmore, Princeton University
4:00 PM – 6:00 PM Concurrent Session 2
Lahaina 3 and 4
Cell-type and Context-Specific Effects of Genetic Risk Variants for Neuropsychiatric Disorders, Chair: Jason Stein, University of North Carolina at Chapel Hill
Cell-Type and Context-Specific Genetic Influences on Chromatin Accessibility, Expression, and Proliferation in Human Neural Progenitor Cells and Neuronal Progeny,
Jason Stein, University of North Carolina at Chapel Hill
Brain Cell-Type Regulatory Landscapes and Associations with Disease,
Alexi Nott, Imperial College London
Revisiting the Hypothesis for Prioritizing Schizophrenia Risk Variants,
Hyejung Won, University of North Carolina at Chapel Hill
In vivo Perturb-Seq: Scalable Investigation of Gene Function in the Developing Brain,
Xin Jin, Dorris The Scripps Research Institute
6:00 PM – 6:15 PM Break
6:15 PM – 8:15 PM Concurrent Session 1
Lahaina 1 and 2
iPSC-Based Platform Development for Major Psychiatric Disorder Modeling and Discovery, Chair: Kimberly Christian, University of Pennsylvania
Characterization of Astrocyte-Derived Exosomes in Bipolar Disorder and Their Impact on Recipient Neurons,
Daniel Schill, University of Michigan Medical School
Using iPSCs to Investigate the Impact of Schizophrenia-Associated Risk Genes on Neuronal Activity and Synaptic Function,
Kimberly Christian, University of Pennsylvania
Modeling Plasticity of Human iPSC-Derived Neurons on Multi-Electrode Arrays,
Anne Bang, Sanford Burnham Prebys Medical Discovery Institute
6:15 PM – 8:15 PM Concurrent Session 2
Lahaina 3 and 4
Establishing Brain-Behavior Relationships with Neuromodulation, Chair: Nolan Williams, Stanford University
Circuit-Targeted Neuromodulation Across Symptoms and Disorders,
Shan Siddiqi, Harvard Medical School, Brigham and Women’s Hospital
How Will I Know if Its Working? Monitor-Markers for Therapeutic rTMS?
Jonathan Downar, University of Toronto
Probing and Rescuing Dysfunctional Brain Circuits in Depression,
Conor Liston, Weill Cornell Medicine
Applying Spaced Theta Burst Stimulation to Modulate the Neural Circuitry Underlying Neuropsychiatric Illness,
Nolan Williams, Stanford University
7:00 AM – 9:00 AM Concurrent Session 1
Lahaina 1 and 2
Decoding Prefrontal Cortical Physiology: Circuits and Novel Molecular Targets in Health and Disease, Chair: Nikolaos Mellios, University of New Mexico Health Sciences Center
Prefrontal Reprogramming of Sensory Cortex in Health and Disorders,
Abhishek Banerjee, Newcastle University
Neuro Modulation of Executive Function in the PFC: A Pharmacological Approach,
Eleni Tzavara, CNRS
Glutamatergic Modulation of the Cortex: The Role of NMDAR in Learning and Flexibility,
Jonathan Brigman, University of New Mexico, School of Medicine
Involvement of the Cortico-Striatal Circuits in the Development of Food-Addiction,
Rafael Maldonado, University Pompeu Fabbra
7:00 AM – 9:00 AM Concurrent Session 2
Lahaina 3 and 4
Leveraging the Psychiatric Disease Spectrum Towards an Improved Understanding of Brain Dysfunction, Chair: Marc Fuccillo, University of Pennsylvania
Cross-CNV Single-Cell RNA Sequencing Analysis of Mouse Models to Study Overlap Between Diagnoses,
Jens Hjerling Leffler, Karolinska Institutet
Aberrant Sensory Processing in the 22q11.2 Deletion Mouse Model,
Renata Batista Brito, Albert Einstein College of Medicine
Impact of Nrxn1a Mutations on Neural Circuits for Reward Processing and Motor Control,
Marc Fuccillo, University of Pennsylvania
Functional Interrogation of Disease Associated Copy Number Variants Using Human Pluripotent Stem Cell Based Models,
ChangHui Pak, University of Massachusetts Amherst
9:00 AM to 9:15 AM Break
9:15 AM – 11:15 AM Concurrent Session 1
Lahaina 1 and 2
Genetic Models for Autism Spectrum Disorder, Chair: Bryan Luikart, Dartmouth
Pharmacological Rescue of TCF4-Dependent Myelination Defects in a Mouse Model of ASD,
Brady Maher, Lieber Institute for Brain Development / JHMI
Functional Analysis of ASD Risk Genes in Zebrafish Identifies Convergent Pathways,
Ellen Hoffman, Yale Child Study Center
Precision Genomics in Neuropsychiatric and Neurodevelopmental Disorders Empowered by the New Era of Long-Read Sequencing,
Tychele Turner, Washington University in St. Louis
9:15 AM – 11:15 AM Concurrent Session 2
Lahaina 3 and 4
Microglia at the Synapse – Deciphering the Relevant Mechanisms in Schizophrenia, Chair: Martin Schalling, Karolinska Institutet
From Risk to Mechanism – The Role of Glia at the Synapse in Early Schizophrenia,
Carl Sellgren, Karolinska Institutet
Maturation of Schizophrenia-Associated Circuits: Implementation of Single Cell and Spatial Omics,
Konstantin Khodosevich, University of Copenhagen
Ultrastructural Relationships Between Microglia and Synapses,
Marie-Eve Tremblay, University of Victoria
Microglia and Sensory Modility,
Hiroaki Wake, Nagoya University Graduate School of Medicine
11:15 AM – 1:00 PM Lunch (on your own)
1:00 PM – 3:00 PM Concurrent Session 1
Lahaina 1 and 2
Synapse and Circuit Mechanisms Underlying the Etiology of Neurodevelopmental Disorders, Chair: Katherine Roche, National Institutes of Health-NINDS
Neuroligins and Autism: Insights From Rare Variants,
Katherine Roche, National Institutes of Health-NINDS
Autism-Associated Cellular Mechanisms Shaping Cortical Circuit Assembly,
Gavin Rumbaugh, The Scripps Research Institute, Florida
Ectodomain Shedding by CNTNAP2 Modulates Calcium Homeostasis and Network Synchrony,
Peter Penzes, Northwestern University
NMDA Receptor Dysfunction in Mouse Models of Autism Spectrum Disorders,
Eunjoon Kim, Institute for Basic Science
1:00 PM – 3:00 PM Concurrent Session 2
Lahaina 3 and 4
Novel Molecular Analysis of Human Postmortem Brain, Chair: Colleen McClung, University of Pittsburgh
Cell-Type and Spatially Resolved Molecular Signatures in Human Brain Disorders,
Keri Martinowich, Lieber Institute for Brain Development
Epigenomic Determinants of Chromosomal Organization in Prefrontal Cortex of Subjects with Schizophrenia and Bipolar Disease,
Schahram Akbarian, Icahn School of Medicine at Mount Sinai
Investigating The Proteome Across Space and State in Human Postmortem Brain Tissue,
Matthew MacDonald, University of Pittsburgh
Circadian and Ultradian Rhythms in Human Brain and Changes in Schizophrenia,
Colleen McClung, University of Pittsburgh
3:00 PM – 4:00 PM MPA Business Meeting: Planning for the Future
Lahaina 1 and 2