2014 Molecular Psychiatry Meeting Schedule

 

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7:45 to 9:45 AM Concurrent Session 1
Pacific Room D+E

Memory Suppressors, Memory Engrams, and Forgetting: Ron Davis, Chair, and Joe Tsien, Co-Chair

Joe Tsien, Georgia Regents University: The Conserved Functional Connectivity Motifs Across the Brain’s Memory Circuits

Christina Alberini, New York University: From Memory Suppression to the Development of PTSD-like Phenotypes in Rats

Ron Davis, Scripps Research Institute Florida: Memory Suppressors and Forgetting

Xu Liu, Northwestern University: Optogenetic Manipulations of Memory Engrams

 

7:45 to 9:45 AM Concurrent Session 2
Pacific Room B+C

Novel Model Systems in Mental Illness: Ben Cheyette, Chair and David Krantz, Co-Chair

Lucia Carvelli, University of North Dakota: C. Elegans as a Model System to Study Drug Addiction

David Krantz, UCLA: Analysis of Neurotransmitter Release and Drug Development in Drosophila

Ellen Hoffman, Yale: Functional Analysis of Genes in Autism in a Zebrafish Model

Benjamin Cheyette, UCSF: Mouse Models for Psychiatry Based on SNPs in Wnt Pathway Genes

 

9:45 to 10:00 AM Break

 

10:00 to 12:00 PM Concurrent Session 1
Pacific Room D+E

Elucidating the Disease Function of Psychiatric Genetic Risk Variants: Tracey Petryshen, Chair and Neville Sanjana, Co-Chair

Tracey Petryshen, Harvard/Massachusetts General Hospital: Diverse Brain Functions of the Ankyrin 3 Bipolar Disorder Risk Gene

Omer Durak, Massachusetts Institute of Technology: CHD8, an Autism Spectrum Disorder Risk Gene, Regulates Neurogenesis and Wnt Signaling

Bryan Luikart, Dartmouth Medical School: The Impact of Pten Mutations on Neuronal Form and Function – A Model for Autism

Neville Sanjana, MIT and Broad Institute: Genome-wide CRISPR-Cas9 Knockout Screening in Human Cells

 

10:00 to 12:00 PM Concurrent Session 2
Pacific Room B+C

Genetics of Mood Disorders: Fernando Goes, Chair and Peter Zandi, Co-Chair

Nelson Freimer, University of California, Los Angeles: Family Sequencing of Bipolar Disorder

Eli Stahl, Mt Sinai: Current Status of Rare and Common Variation in Bipolar Disorder

Kelly Benke, Johns Hopkins: Rare Variant Discovery Using Whole Genome Sequencing of Schizophrenia and Bipolar Disorder Pedigrees from the Azorean Islands.

Dick McCombie, Cold Spring Harbor Laboratory: Sequencing of Major Depressive Disorder Families

 

12:00 to 1:30 PM Lunch (on your own)

 

1:30 to 2:30 PM Plenary
Pacific Room D+E

Chemical and Synthetic Neurobiology: Bryan Roth, University of North Carolina. Introduction: Daniel Weinberger

 

2:30 to 2:45 PM Break

 

2:45 to 4:45 PM Concurrent Session 1
Pacific Room D+E

Neural Network Dysfunction across the Mood Disorders Spectrum in Youth and Adults: Jair Soares, Chair and Kiki Change, Co-Chair

Melissa DelBello, University of Cincinnati: The Neuroprogression of Prefrontal Dysfunction in Youth With and At-Risk for Developing Mania

Kiki Chang, Stanford University: Brain Morphometric and Functional Characteristics of Youth With Mood Disorders Secondary to Pediatric Acute Onset Neuropsychiatric Syndrome (PANS)

Wayne Drevets, Laureate Institute for Brain Research: Precedence, Persistence and Relationship to Treatment of Negative Emotional Processing Biases in Major Depressive Disorder

Jair Soares, University of Texas Medical School, Houston:  Bipolar Disorders – From Putative Brain Mechanisms to Possible Endophenotypes

 

2:45 to 4:45 PM Concurrent Session 2
Pacific Room B+C

Genetics of Schizophrenia: Anil Malhotra, Chair and Bill Byerley, Co-Chair

Anil Malhotra, Genetic Factors Influencing White Matter Development in Schizophrenia

Aiden Corvin, Trinity College: Schizophrenia genomics: new strategies in the sequencing era

Bill Byerley, WGS and Identification of Schizophrenia Risk Alleles in Palau

Jim Kennedy, University of Toronto: Contrasting Different Gene Sets in Schizophrenia: Glutamate, Dopamine, Immune and Synaptic

 

7:45 to 9:45 AM Concurrent Session 1
Seacliff Room C+D

Neurobiology of Risk Genes for Schizophrenia: Chair, Hongjun Song and Co-Chair, Danny Weinberger

Lin Mei, Georgia University: Neuregulin/ErbB4 Regulation of Interneuron Circuitry

Amanda Law, University of Colorado Denver: AKT2 & AKT3: Roles in cognitive development and behaviors relevant to schizophrenia

Sanbing Shen, National University of Ireland: Neurodevelopmental Deficits of the Ulk4 Mutant Mice

Brady Maher, Lieber Institute: The Schizophrenia and Autism Spectrum Disorder gene TCF4 Regulates Cortical Structure and Neuronal Physiology

Sandra Siegert, MIT: The schizophrenia Risk Gene MicroRNA-137 Regulates Synaptic Transmission

Zhexing Wen, Johns Hopkins University: Deficits in Core Synaptic Signatures in a Human iPSC Model of Mental Disorders

 

7:45 to 9:45 AM Concurrent Session 2
Seacliff Room B

Neurobiologic Pathways in Bipolar Disorder: John Nurnberger, Chair and Mark Vawter, Co-Chair

Phil Lee, Broad Institute: Pathway Analyses of PGC GWAS Data Implicate a Role of Altered Histone Methylation in Bipolar Disorder

John Nurnberger, Identification of Pathways for Bipolar disorder: A Meta-analysis

Hiroaki Tomita, Tohoku University: Glial Involvement in the Mechanism of Action of Mood stabilizers and the Pathophysiology of Bipolar Disorder

Ping-I (Daniel) Lin, Corticolimbic System and Inflammatory Genetic Factors in Emotion Arousal Associated with Bipolar Disorder

Yokesh Balaraman, Indiana University: Identification of Pathways and Target Genes in Lithium Treated Neuronal Cultures.

Geert Poelmans, Radboud University: An Integrated Molecular Landscape for Bipolar disorder: Searching for the Molecular Switch(es)

 

9:45 to 10:00 AM Break

 

10:00 to 12:00 PM Concurrent Session 1
Seacliff Room C+D

Autism Genetics: Lauren Weiss, Chair and Elise Robinson, Co-Chair Elise

Elise Robinson, Harvard University: ASD Heterogeneity: Associating Phenotypic Severity with Genetic Architecture

Dave Cutler, Emory University: Using Quantitative Genetics to Understand Male / Female Differences in Autism Susceptibility Alleles

Virpi Leppa, University of California, Los Angeles: Expanding Autism Research to Underrepresented Populations

John Constantino, Washington University: Sex, Genetic Background, and Mutational Specificity in the Transmission of Quantitative Autistic Traits

Alexandre Reymond, University of Lausanne: Chromosomal Contacts Connect Loci Associated with Autism, BMI and Head Circumference Phenotypes

 

10:00 to 12:00 PM Concurrent Session 2
Seacliff Room B

New Findings on the Genetics of Alcohol and Drug Use Disorders: Howard Edenberg, Chair and Cindy Ehlers, Co-Chair

Howard J Edenberg, Indiana University: Genetics of Alcoholism and Substance Dependence: Family Studies

Marissa Ehringer, University of Colorado, Boulder: Molecular Genetics of Nicotinic Receptor Genes

Cindy Ehlers, Scripps Research Institute: Contributions to Substance Dependence in Native Americans.

Ian Gizer, University of Missouri: Genetic Analysis of Cannabis Dependence in a Native American Population Using Low-Coverage Whole Genome Sequence Data

 

12:00 to 1:30 PM Lunch (on your own)

 

1:30 to 2:30 PM Plenary
Pacific Room C+D

Modeling Cellular and Molecular Mechanisms of Human Neuropsychiatric Disease with Stem Cell Technology: Rusty Gage, Salk Institute.  Introduction, John Kelsoe

 

2:30 to 2:45 PM Break

 

2:45 to 4:45 PM Concurrent Session 1
Seacliff Room C+D

Neuroimaging the Evolution of Psychosis: Chair, Raquel Gur and Co-Chair, Ruben Gur

Ruben C. Gur, University of Pennsylvania: Multimodal Imaging in a Population-Based Sample: Developmental Warning Signals Before Psychosis Hits

Carrie Bearden University of California, Los Angeles: Neuroimaging in Clinical and Genetic High Risk Studies

Cameron Carter, University of California, Davis: Imaging Functional Circuitry and Molecular Pathophysiology in First Episode Schizophrenia

Judith Ford, University of California, San Francisco: Using Simultaneously Acquired EEG and fMRI to Understand Deficits in Predictive Coding in Schizophrenia

 

2:45 to 4:45 PM Concurrent Session 2
Seacliff Room B

Moving from Gene to Mechanisms in Autistic Disorders: Dan Geschwind, Chair and Matt State, Co-Chair

Jim Noonan, Yale University: CDH8 Pathways

Craig Powell, University of Texas Southwestern Medical Center: Genetic Models of Autism: Molecules to Potential Therapeutics

Dan Geschwind, University of California, Los Angeles: CNTNAP2 Mechanisms

Richard Tsien, New York Unversity: Oxytocin Modulation of Cortical Function

 

7:45 to 9:45 AM Concurrent Session 1
Seacliff Room C+D

Recent Advances in the Gamma-Band Auditory Steady-State Response as a Psychosis Endophenotype: Kevin Spencer, Chair and Raymond Y. Cho, Co-Chair

Kevin M. Spencer, Harvard: Insights Into the Risk and Development of Psychosis from the ASSR

Raymond Cho, University of Texas Medical School, Houston: The Auditory Steady State Response: Tracking Gamma Oscillations in Development, Psychosis and Drug Interventions

Patrick Skosnik, Yale: It’s all in the Waves: Cannabinoids, Neural Oscillations, and Psychosis

Digavalli Sivarao, Bristol Myers Squib: Disinhibition and Inhibition: Ketamine’s Effects on the 40 Hz Auditory Steady State Response in the Awake Rat

Daniel Mathalon, University of California, San Francisco: Effects of Ketamine and Schizophrenia on Gamma Oscillations

 

7:45 to 9:45 AM Concurrent Session 2
Seacliff Room B

OMICS Approaches to Unravel the Complexity Psychiatric disorders: Impact on Biomarker Discovery: Chair, Daniel Martins de-Souza and Chris Turck, Co-Chair

David Glahn, Yale: Endophenotypic Complexity in Whole Genome Sequence Era

Marquis Vawter, University of California, Irvine: Mitochondrial Variants in Psychiatric Disorders

David Cotter, Royal College of Surgeons In Ireland: Insights into Schizophrenia from Proteomic Analysis of Postsynaptic Density and Olfactory Neurosphere derives Stem Cells

Cyndi Weickert, University of New South Wales: From Next Generation Sequencing of Human Brain Transcriptome to Identification of Biomarkers of Neuropathology in Blood

 

9:45 to 10:00 AM Break

 

10:00 to 12:00 PM Concurrent Session 1
Seacliff Room C+D

Early Developmental Predictors of Mental Illness Risk: Pat Levitt, Chair and Nathan Fox, Co-Chair

Mark Ansorge, Columbia University: Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Kim McAllister, University of California, Davis: Maternal Infection and its Impact on Synapse Development and Function in Relation to Mental Illness Risk

Nathan Fox, University of Maryland: Early Deprivation and the Roots of Cognitive and Emotional Dysfunction

Pat Levitt, Children’s Hospital Los Angeles and University of Southern California: Allostasis as a Developmental Mechanism that Leads to Mental Illness Risk

 

10:00 to 12:00 PM Concurrent Session 2
Seacliff Room B

Childhood Genetics: Carol Matthews, Chair and Ben Neale, Co-Chair

Ben Neale, Broad Institute:  Establishing the Role of Common Variation in risk to Attention Deficit/Hyperactivity Disorder

Jonathan Coleman, Kings College: The Genes for Treatment Study: A Therapy Genetics GWAS of Response to Cognitive Behavioral Therapy in Children with Anxiety Disorders

Christie Burton, The Hospital for Sick Children: A Genome Wide Association Study of Quantitative Obsessive-Compulsive Traits in a Community Based Sample of Children and Adolescents

Erika Nurmi, UCLA: Toward Individualized Treatment Matching: Pharmacogenomics in Child Psychiatry?

 

12:00 to 1:30 PM Lunch (on your own)

 

1:30 to 2:30 PM Plenary
Seacliff Room C+D

Psychiatry in the Discovery Era: How Do We Go From Genes to Targets? Tom Insel, NIMH. Introduction, Rob Malenka

 

2:30 to 2:45 PM Break

 

2:45 to 4:45 PM
Seacliff Room C+D

Gene Expression: the Rosetta Stone for Psychiatric Disorders: Bob Niculescu and Akira Sawa, Co-Chair

Daniel R. Weinberger, Lieber Institute for Brain Development: Trancriptome Dynamics of Neurodevelopmental Disorders

Alexander B. Niculescu, Indiana University: Next Generation Blood Gene expression Biomarkers for Psychiatric Disorders

Akira Sawa, Johns Hopkins University: SMAD Signaling and Cognitive Deficits in Schizophrenia: a Molecular Expression Study with Biopsied Olfactory Neurons