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Thursday, October 17, 2019

6:30 am – 8:00 am – Breakfast

8:00 am – 10:00 am – Symposia Sessions

Neuronal Ectodomain Shedding and Ectodomain-Mediated Signaling: Implications for Pathogenesis, Biomarkers, and Therapies

Chair: Peter Penzes, Northwestern University

  • Myelin Plasticity in Health and Disease, Michelle Monje-Deisseroth, Stanford
  • Ectodomain Shedding as a Molecular Switch to Establish Functional Synaptic Networks, Hisashi Umemori, Massachusetts General Hospital/Harvard
  • Novel Functions of Synaptic Ectodomains Detectable in the CSF, Peter Penzes, Northwestern University
  • Regulation of Basket Interneuron Connectivity in the Prefrontal Cortex through NCAM Shedding and EphA3 Signaling, Patricia F. Maness, University of North Carolina

Cellular and Molecular Mechanisms of Neurodevelopmental and Psychiatric Disorders

Chair: Karun K. Singh, Stem Cell and Cancer Research Institute, McMaster University
Co-Chair: Kristen Brennand, Icahn School of Medicine at Mount Sinai
Presenters:

  • Hypoxia-induced Corticogenesis Defects in a Human Cellular Model of Brain Injury of Prematurity, Anca Pasca, Stanford University
  • A Platform to Identify Autism-associated Protein Interaction Networks, Karun Singh, Stem Cell and Cancer Research Institute, McMaster University
  • Using Stem Cells to Explore the Genetics Underlying Neuropsychiatric Disease, Kristen Brennand, Icahn School of Medicine at Mount Sinai
  • Prioritization of Potential Therapeutic Targets by Analysis of Postmortem Human Schizophrenic Brain and Induced Pluripotent Stem Cell Models, Jennifer A. Erwin, Lieber Institute for Brain Development

10:00 am – 10:15 am – Break

10:15 am – 12:15 pm – Symposia Sessions

Molecular Models for Autism Spectrum Disorders

Chair: Bryan Luikart, Geisel School of Medicine at Dartmouth
Co-Chair: Brady J. Maher, Lieber Institute for Brain Development
Presenters:

  • Do Defects in Oligodendrocytes Contribute to Pathophysiology in Autism Spectrum Disorders?, Brady J. Maher, Lieber Institute for Brain Development
  • Investigating the Molecular Basis of Autism Using Mouse and Human Brain Organoid Models of Tuberous Sclerosis Complex, Helen Bateup, University of California, Berkeley
  • Studying Macrocephalic Autism Using iPSC, Carol Marchetto, Salk Institute for Biological Studies
  • Distinct Regulation of Local and Long-range Neocortical Synaptic Connections by MEF2C and FMRP, Kimberly Huber, University of Texas Southwestern

Sleep, Circadian Rhythms and Genetics

Chair: Hanna M. Ollila, Stanford University
Co-chair: Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT
Presenters:

  • Shared Genetic Underpinnings of Sleep and Psychiatric Disorders, Jacqueline Lane, Massachusetts General Hospital, Center for Genomic Medicine and Broad Institute for Harvard and MIT
  • USF Transcription Factors Regulate Sleep and Circadian Rhythms, Nasa Sinnott-Armstrong, Stanford University
  • A Novel Target to Modulate Wakefulness and Cognition – the Neurosteroid Approach, Martin Schalling, Karolinska Institutet
  • Sleep Control Across Lifespan, Luis de Lecea, Stanford University

12:15 pm – 2:00 pm – Mid-day Break (Lunch on your own)

2:00 pm – 3:00 pm – Plenary

Molecular, Cellular and Circuit-level Control of Social Behaviors, Catherine Dulac, Harvard University, Higgins Professor of Molecular and Cellular Biology

3:00 pm – 3:15 pm – Break

3:15 pm – 5:15 pm – Symposia Sessions

Beyond the Central Dogma: From Junk DNA to Brain Disorders

Chair: Alexandre Cristino, Griffith Institute for Drug Discovery, Griffith University
Co-chair: Hyejung Won, University of North Carolina
Presenters:

  • Detection on Noncoding Risk Factors for Autism Spectrum Disorder with Whole-genome Sequencing, Stephan Sanders, School of Medicine, University of California, San Francisco
  • Functional Dissection of Neural Enhancers Using Massively Parallel Reporter Assays, Fumitaka Inoue, School of Pharmacy, University of California, San Francisco
  • Connecting Gene Regulatory Relationships to Neurobiological Mechanisms of Brain Disorders, Hyejung Won, University of North Carolina
  • Unravelling the Functional Effects of Rare microRNA Mutations Identified in Schizophrenia Patients, Alexandre Cristino, Griffith Institute for Drug Discovery, Griffith University

The Role of Puberty in Brain Maturation: Relevance to Psychiatric Disease Risk

Chair: Kristen Delevich, University of California, Berkeley
Co-chair: Megan Herting, University of Southern California

  • Pubertal Maturation and Structurally Distinct Amygdala Subregion Development in Children and Adolescents, Megan Herting, University of Southern California
  • Sex-specific Effects of Puberty on Approach-avoidance Behavior and Dendritic Spine Pruning, Kristen Delevich, University of California, Berkeley
  • Sexual Differentiation of Neural Circuits of Social Anxiety, Brian Trainor, University of California, Davis
  • The Influence of Puberty on Neural Systems of Social Threat and Reward: Links to Anxiety and Depression Risk, Cecile Ladouceur, University of Pittsburgh

Friday, October 18, 2019

6:30 am – 8:00 am – Breakfast

8:00 am – 10:00 am – Symposia Sessions

Synaptic Pathologies in Neurodevelopmental Disorders

Chair: Bruce Herring, University of Southern California
Co-chair: Kevin Bender, University of California, San Francisco
Presenters:

  • The Role of RhoGEF Proteins in Synaptic Transmission and Neurodevelopmental Disorders, Bruce Herring, University of Southern California
  • Progress Toward Pharmacological Targeting of Synaptic Small GTPase Pathways, Peter Penzes, Northwestern University
  • Scn2a Dysfunction in Neurodevelopmental Disorders, Kevin Bender, University of California, San Francisco
  • CRISPR Nanoparticle-mediated Gene Editing in the Mouse Model of Fragile X Syndrome, Hye Young Lee, The University of Texas, Health Science Center at San Antonio

Proteomic Technologies Applied to Neuroscience

Chair: Ruth Hüttenhain, University of California, San Francisco
Co-chair: Nevan Krogan, University of California, San Francisco
Presenters:

  • Using Proteomic Approaches to Understand the Mechanism of Disease, Nevan Krogan, University of California, San Francisco
  • Proximity Labeling: Spatiotemporally-resolved Proteomics and Transcriptomics for Neuroscience, Shui Han, Stanford
  • Identification of Spatiotemporally-resolved GPCR Protein Interaction Networks Regulating Receptor Function, Ruth Hüttenhain, University of California, San Francisco
  • Mapping the Protein-protein Interaction Networks of Autism Spectrum Disorder Risk Genes, Yefim Zaltsman, University of California, San Francisco
  • Multi-omics Mapping Reveals Protein Dynamics in Neuronal Differentiation, Dmitry Kuchenov, University of California, San Francisco

10:00 am – 10:15 am – Break

10:15 am – 12:15 pm – Symposia Sessions

Beyond GWAS – Finding Hidden Genetic Features of Neuropsychiatric Disorders

Chair: Donard S. Dwyer, LSU Health Shreveport
Co-Chair: Xiao-Hong Lu, LSU Health Shreveport
Presenters:

  • Genetic Variants Affecting Chromatin Accessibility During Human Neuronal Differentiation, Jason Stein, University of North Carolina
  • Novel Single-neuron and Genome-editing Tools to Unravel the Pathogenic Significance of Brain Somatic Mosaicism, Xiao-Hong Lu, LSU Health Shreveport
  • DNA Epigenetic Modifications in Drug Addiction, Jian Feng, Florida State University
  • Role of Genetic Interactions in Schizophrenia Risk, Merve Kasap, Vanderbilt University

Neural Circuit Basis of Adult Hippocampal Neurogenesis in Cognition and Emotion 

Chair: Juan Song, University of North Carolina, Chapel Hill
Co-Chair: Amar Sahay, MGH, Harvard University
Presenters:

  • Dysregulation of Hippocampal Adult-born Neurons Disrupts Brain-wide Functional Network Associated with Memory, Juan Song, University of North Carolina, Chapel Hill
  • Neurogenesis, Memory Interference and Generalization, Amar Sahay, MGH, Harvard University
  • Hippocampal Neurogenesis and Forgetting, Paul Frankland, SickKids, University of Toronto
  • BMP Regulation of Hippocampal Neurogenesis Mediates the Behavioral Effects of Antidepressants, Jack Kessler, Northwestern University
  • The Modulatory Function of Adult Hippocampal Neurogenesis: Impact on Mood and Cognition, Rene Hen, Columbia University

12:15 pm – 2:00 pm – Mid-day Break (Lunch on your own)

2:00 pm – 4:00 pm – Symposia Sessions

Maternal Immune Challenge and Neuropsychiatric Disorders

Chair: Alex Nord, University of California, Davis
Co-Chair: Melissa Bauman, University of California, Davis
Presenters:

  • Maternal Immune Activation Perturbs Temporal Progression of Cerebral Cortex Development in Mouse, Alex Nord, University of California, Davis
  • Chronic Maternal Interleukin-17 and Autism-related Cortical Gene Expression, Neurobiology, and Behavior, Hanna Stevens, University of Iowa
  • Modeling Gene-Immune Interactions in Altered Neurodevelopment, Theo Palmer, Stanford University
  • Nonhuman Primate Model of Maternal Immune Activation, Melissa Bauman, University of California, Davis

Neurotransmitter Transporters and Neuropsychiatric Illness

Chair: David E. Krantz, University of California, Los Angeles
Co-Chair: Susan Voglmaier, University of California, San Francisco

  • Different Modes of Release for Different Neurotransmitters, Robert H. Edwards, University of California, San Francisco
  • New Roles for VGLUT in DA Neuron Physiology and Vulnerability, Zachary Z. Freyberg, University of Pittsburgh
  • Model Systems for Examining Antidepressant Mechanism of Action, David E. Krantz, University of California, Los Angeles
  • The Ins and Outs of Amphetamine Action, Jonathan A. Javitch, Columbia University

4:00 pm – 4:15 pm – Break

4:15 – 5:30 pm – Poster Talks

5:30 pm – 7:30 pm – Poster Session/Reception

Saturday, October 19, 2019

6:30 am – 8:00 am – Breakfast

8:00 am – 10:00 am – Symposia Sessions

Using Molecular and Neuroimaging Biomarkers to Dissect the Heterogeneity of Psychiatric Illness

Chair: Anil Malhotra, Zucker Hillside Hospital
Co-chair: Katherine Burdick, Harvard University
Presenters:

  • Abnormal Cytokine and Complement C4 Levels in Cerebrospinal Fluid and Plasma Samples of Patients with Schizophrenia and Healthy Volunteers, Juan Gallego, Zucker Hillside Hospital
  • Data-Driven Brain-Behavior Subtypes Across Disorders, Aristotle Voineskos, University of Toronto
  • Interaction Between Antipsychotic Exposure and Striatal Connectivity in Psychotic Relapse, José Rubio-Lorente, Zucker Hillside Hospital
  • Inflammatory Biomarkers of Cognitive Function in Bipolar Disorder, Katherine Burdick, Harvard University

Pluripotent Stem Cell Models of Rare and Common Genetic Risk for Psychiatric Disorders

Chair: Ralda Nehme, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT
Co-chair: Brady J. Maher, Lieber Institute for Brain Development
Presenters:

  • The 22q11.2 Microdeletion: How Might it Produce Different Neuropsychiatric Phenotypes?, Ralda Nehme, Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT
  • Modeling Human Brain Development and Disease at Single Cell Resolution with Brain Organoids, Giorgia Quadrato, Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC
  • Developmental Impact of Patient-specific TCF4 Mutations on the In Vitro Cortical Circuit, Brittany A. Davis, Lieber Institute for Brain Development
  • Modeling Schizophrenia and its Polygenic Risk Using Induced Pluripotent Stem Cell-derived Neurons, Daniel J. Hiler, Lieber Institute for Brain Development

10:00 am – 10:15 am – Break

10:15 am – 12:15 pm – Symposia Sessions

Towards Precision Psychiatry Through Genomics and Pharmacology

Chair: John Kelsoe, University of California, San Diego
Co-chair: Alexander Charney, Icahn School of Medicine at Mount Sinai
Presenters:

  • Investigating the Mechanisms of Psychotropic Drugs Through Genomics, Alexander Charney, Icahn School of Medicine at Mount Sinai
  • Modeling Genetic Risk Variants in Schizophrenia, Carl Sellgren, Karolinska Institutet
  • Studying Mood Disorders Using Patient iPSC-derived Cells In Vitro, Krishna Vadodaria, Salk Institute
  • Identifying Gene Pathways in Lithium Response Using an iPSC Model, John Kelsoe, University of California, San Diego

Circadian Rhythm Abnormalities in Bipolar Disorder: Genetic, Molecular and Behavioral Advances in Human Subjects

Chair: Michael McCarthy, University of California, San Diego
Presenters:

  • Association of Bipolar Disorder and Clinical Phenotypes with Genetic Variants of Circadian Genes, Suzanne Gonzalez, Penn State University
  • Using Stem Cell Derived Neurons to Model Circadian Rhythm Abnormalities in Bipolar Disorder, Michael McCarthy, University of California, San Diego
  • Molecular Rhythm Changes in Postmortem Brains from Subjects with Bipolar Disorder and Schizophrenia, Kyle Ketchesin, University of Pittsburgh
  • Actigraphic Analysis of Bipolar Disorder Patients Reveals Circadian Sub-phenotypes, Robert Gonzalez, Penn State University

12:15 pm – 2:00 pm – Mid-day Break (Lunch on your own)

2:00 pm – 3:00 pm – Plenary Session

In Search of the Engram, Mark Mayford, Department of Psychiatry, UCSD School of Medicine

3:00 pm – 3:15 pm – Break

3:15 pm – 5:15 pm – Symposia Sessions

Excitatory-inhibitory Dynamics from Synapses to Systems: Bridging Rodents to Humans to Examine how the Brain Responds to Perturbation in Neurodevelopmental Conditions

Chair: Grainne McAlonan, King’s College London
Presenters:      

  • Shank3 is a Critical Determinant of Homeostatic Plasticity, Vedakumar Tatavarty, Brandeis University
  • Using Multiple Non-invasive Modalities to Study the Role of Altered Inhibition in Children with Autism Spectrum Disorder, Nick Puts, Johns Hopkins University
  • Visual Perception as a Window into Circuit-level Differences in the Human Autistic Brain, Caroline Robertson, Dartmouth College
  • Probing Dynamics of Excitation/Inhibition Pathways in Autism Spectrum Condition – a Pharmacological Neuroimaging Approach, Andreia Carvalho Pereira, King’s College London

The Psychiatric Cell Map Initiative: Overview and Current Results

Chair: Jeremy Willsey, University of California, San Francisco
Presenters: TBD

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