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6:30AM to 7AM Breakfast

7:00 to 9:00 AM

iPSC-based platform development for major psychiatric disorder modeling and discovery: Chair, Guang Chen, Janssen R&D LLC., Johnson and Johnson; Co-chair, Sue O’Shea, University of Michigan

“Using patient-derived neural cells to study Bipolar Disorder – Carol Marchetto, Salk Institute”

Role of CACNA1C—a shared risk factor in neuropsychiatric disorders – Katarzyna Glanowska, University of Michigan

Role of a psychiatric disease risk factor in synaptic function and gene transcription regulation – Kimberly Christian, University of Pennsylvania Perelman School of Medicine

Phenotypic screening of hiPSC derived neurons: Balancing throughput with relevance – Anne Bang, Sanford Burnham Prebys Medical Discovery Institute

7:00 to 9:00 AM

The new kid on the block: glia in mental and cognitive disorders: Chair: Misha Pletnikov, Johns Hopkins University School of Medicine; Co-chair: Robert McCullumsmith, University of Cincinnati

Bioenergetic defects in severe mental illness: An intermediate phenotype that links genomic risk with psychopathology? – Robert McCullumsmith, University of Cincinnati

Genetic risk factors in neuron-astrocyte energy coupling and cognitive dysfunction – Mikhail Pletnikov, Johns Hopkins University School of Medicine

Contribution of glia and extracellular matrix interactions to the pathophysiology of schizophrenia and bipolar disorder – Harry Pantazopoulos, Harvard Medical School

Experience-dependent plasticity of astrocytes – Kathryn Reissner, University of North Caroline at Chapel Hill

9:15 to 11:15 AM

Diseases of the social brain: Chair, Gul Dolen, Johns Hopkins; Co-chair, Andreas Meyer Lindenberg, Central Institute of Mental Health

Neural mechanisms of social risk for schizophrenia – Andreas Meyer-Lindenberg, Central Institute of Mental Health Mannheim

Evidence Base for Phase 3 Trials of MDMA-assisted Psychotherapy, a Breakthrough-Designated Treatment for PTSD – Berra Yazar-Klosinski, Multidisciplinary Association for Psychedelic Studies

Probing social motivation in autism – Barbara Thompson, University of Southern California

Social reward learning: basic mechanisms and therapeutic opportunities – Gul Dolen, Johns Hopkins

9:15 to 11:15 AM

Calcium Mechanisms in Bipolar Disorder: A review of genetic evidence and cellular models: Chair, John Nurnberger, Indiana University School of Medicine; Co-chair, John Kelsoe, UCSD

Introduction – John Kelsoe, UCSD

Genetic data and gene expression data supporting calcium involvement in bipolar disorder – Ney Alliey-Rodriguez, University of Chicago

Characterizing rare variants that influence risk for bipolar disorder – Seth Ament, University of Maryland School of Medicine

L-type voltage-gated calcium channels: complex proteins; complex phenotypes – Geoff Murphy, University of Michigan

Mechanisms underlying hyperexcitability in hippocampal neurons derived from bipolar disorder patients in experiment and computational modeling – Shani Stern, Salk Institute

11:30 AM to 1:30 PM

Utilizing diversity of model organisms for studying the molecular basis of neuropsychiatric disorders: Chair, Michael Yartsev, UC Berkley; Co-chair, Daniel Kronauer, Rockefeller University

Communication and Social Behavior in Ants – Daniel Kronauer, Rockefeller University

Neural circuit mechanisms of valence processing – Kay Tye, MIT

Fronto-striatal control of anxiety-like behavior – Lisa Gunaydin, UCSF

Neurobiological mechanisms of vocal production learning of social calls – Michael Yartsev, UC Berkley

11:30 AM to 1:30 PM

ISN Symposium: Molecular insights on organoid and 3D models to study brain diseases and development: Chair, Orly Reiner, Weizmann Institute of Science; Co-chair, Jeremy Crook, University of Wollongong

Using human brain organoids to model ASD and schizophrenia – Mandy Johnstone, University of Edinburgh

Modeling of major mental disorders using tissue engineering approaches – Jeremy Crook, University of Wollongong

Live-imaging of human brain organoids for disease modeling – Orly Reiner, Weizmann Institute of Science

Long term maturation of human cortical forebrain spheroids models post-natal brain development – Aaron Gordon, UCLA

1:30 to 7:00 PM Break

7:00 to 8:00 PM

Plenary talk: Rick Huganir “Regulation of Neurotransmitter Receptors in Cognition and Cognitive Disorders”

6:30AM to 7AM Breakfast

7:00 to 9:00 AM

Building on advances in genetics to validate novel molecular targets for treatment of schizophrenia: Chair, Jeff Conn, Vanderbilt University; Co-chair, Amy Arnsten, Yale University

Patient-derived de novo variation of CACNA1I impairs sleep spindles in mice: implication for novel therapeutic strategies – Jen Pan, Stanley Center for Psychiatric Research

AS3MT and Schizophrenia – From GWAS Locus to Chemical Biology Tools – James Barrow, Lieber Institute

The Druggable Genome: Key Actions of mGluR3 in the Prefrontal Cortical Circuits Most Impacted in Schizophrenia – Amy Arnsten, Yale University

Genetic Insights Lead to Discovery of Selective Activators of mGlu1 and mGlu3 Metabotropic Glutamate Receptors as Potential Treatments for Schizophrenia – Jeff Conn, Vanderbilt University

7:00 to 9:00 AM

The Neural Circuitry underlying Social Dysfunction – Chair, Byungkook Lim, UCSD; Co-chair, Weizhe Hong, UCLA

Dysfunction of reward circuits as a consequence of chronic stress – Scott Thompson, University of Maryland

The neural basis of early-life stress induced social dysfunction – Byoungkook Lim, UCSD

Neural circuitry for the innate social behaviors – Weizhe Hong, UCLA

Elucidating neural circuits underlying autism-like behaviors – Gloria Choi, MIT

9:15 to 11:15 AM

Somatic mosaicism in the brain: Diverse Neuronal Genomes and Neuropsychiatric Disorders: Chair, Alexander Urban, Stanford University; Co-chair, Douglas Ruderfer, Vanderbilt University

Machine learning analysis of ultra-deep whole-genome sequencing in human brain reveals somatic retrotransposition in both neurons and glia – Alexander Urban, Stanford University

A functional role of somatic retrotransposition in schizophrenia associated sensorimotor gating deficit – Anindita Sarkar, Salk Institute

Somatic SNVs in brain during aging and in degenerative disorders – Michael Coulter, Harvard Medical School

Human neural progenitor cells harbor DNA double-strand breaks in genes linked to autism – Meiyan Wang, Salk Institute

9:15 to 11:15 AM

Cortico-striatal circuits in addiction and compulsion: Chair, Mark Thomas, University of Minnesota; Co-chair, Michael Bruchas, University of Washington

Interruption of Continuous Opioid Exposure Exacerbates Drug-Evoked Adaptations in the Nucleus Accumbens – Patrick Rothwell, University of Minnesota

Dissecting nucleus accumbens circuits in reward seeking – Michael Bruchas, University of Washington

Individual differences in repetitive behavior associate with striatal neuron subtype transcriptomes – Mary Kay Lobo, University of Maryland

Fronto-striatal connections in decision making and addiction – Mark Thomas, University of Minnesota

11:30 AM to 1:00 PM

Poster Talks

11:30-11:40am:  Corticostriatal circuit defects in Hoxb8 mouse model of repetitivebehaviors – Naveen Nagarajan, University of Utah

11:40-11:50am: Novel diurnal patterns of gene expression in the schizophrenic brain – Colleen McClung, University of Pittsburgh

11:50am-12:00pm: A human stem cell resource for modeling genetic variation – Ralda Nehme, Broad Institute

12:00-12:10pm: Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions – Summer Thyme, Harvard University

12:10-12:20pm:  Altered connectivity in Rett syndrome stem cell-derived cortical neural networks – Rebecca Mok, University of Toronto

12:20-12:30pm: Molecular Insults to Higher-Order Dorsolateral Prefrontal Cortical Circuits: Implications for the Pathogenesis of Schizophrenia – Dibyadeep Datta, Yale University

12:30-12:40pm:  Hyper-excitable neurons produce hypo-functional neuronal networks: Evidence from modeling bipolar disorder with mouse models and hiPSCs – Cameron Pernia, Sanford Burnham Prebys Medical Discovery Institute

12:40-12:50pm: Single-cell transcriptome analysis of embryonic mouse cortex reveals developmental trajectories of ASD risk gene expression – Kristina Yim, Yale School of Medicine

12:50-1:100:  Identification of spatiotemporally resolved GPCR protein interaction networks regulating receptor function – Ruth Huttenhain, UCSF

 

 

1:00 to 6:00 PM Break

6:00 to 8:00 PM

Poster session and reception

6:30AM to 7AM Breakfast

7:00 to 9:00 AM

Molecular mechanisms of Autism Spectrum Disorders: Chair, Brady Maher, Lieber Institute; Co-chair: Brian Luikart, Geisel School of Medicine at Dartmouth

A genomics based approach to the etiology of autism – Tychele Turner, University of Washington

Gene, Brain, and Behavior: interrogating the fundamentals of neurodevelopmental disorders – Xinyu Zhao, University of Wisconsin-Madison

SCN2A in autism spectrum disorder – Kevin Bender, UCSF

Post-Synaptic Neurons of a Mouse Model for Autism Display a Competitive Advantage in Recruiting Pre-Synaptic Inputs – Brian Luikart, Geisel School of Medicine at Dartmouth

Multi-model system approach to functionalizing ASD variants – Kurt Haas, University of British Columbia

7:00 to 9:00 AM

Central and peripheral actions of insulin: Implications for psychiatric disorders: Chair, Michael McCarthy, UCSD; Co-chair, Zachary Freyberg, University of Pittsburgh

Antipsychotics: Effects on brain insulin action in relation to whole body metabolism – Margaret Hahn, University of Toronto

Novel roles for pancreatic dopamine signaling in metabolic regulation and antipsychotic drug action – Zachary Freyberg, University of Pittsburgh

Dopamine receptor regulation of circadian rhythms in beta islet cells: Implications for metabolic side effects of antipsychotic drugs – Michael McCarthy, UCSD

Central Insulin Resistance: Potential mechanistic link to neuropsychiatric disorders – Lawrence Reagan, University of South Carolina

9:15 to 11:15 AM

New molecular and circuit-level approaches for understanding the effects of chronic stress in the mammalian brain – Chair, Stephan Lammel, UC Berkley; Co-chair, Garret Stuber, University of Washington

An extended amygdala circuit to drive hyperarousal – Garret Stuber, University of Washington

Habenular synaptic plasticity in opiate withdrawal – Manuel Mameli, University of Lausanne

Architecture of habenula circuitry underlies a distinct stress-induced depression phenotype – Stephan Lammel, UC Berkley

Sustained rescue of prefrontal circuit dysfunction by antidepressant-induced synaptogenesis – Conor Liston, Weill Cornell Medicine

9:15 to 11:15 AM

Bridging molecular genetics with population health to advance precision psychiatry, Chair, Lea Davis, Vanderbilt University Medical Center; Co-chair, Hae-Kyung Im, University of Chicago

PrediXcan and beyond: methods and tools to dissect the biology of complex traits – Hae-Kyung Im, University of Chicago

Using GWAS, eQTL and PrediXcan (aka TWAS) to understand complex behavioral traits in mice and rats – Abraham Palmer, UCSD

Leveraging electronic health records to advance psychiatric genomics and phenomics – Lea Davis, Vanderbilt University Medical Center

Investigating the causal relationships between mental and physical health outcomes using Mendelian randomization – Chia-Yen Chen, Massachusetts General Hospital

11:30 AM to 1:30 PM

Molecular Mechanisms of Pain Regulation: Chair, Rob Gereau, Washington University in St. Louis; Co-chair, Catherine Cahill, UCLA

Plasticity in endocannabinoid regulation of the descending pain pathway with persistent inflammation – Susan Ingram, Oregon Health & Science University

Intersection between pain and addiction – implications for kappa opioid receptors – Catherine Cahill, UCLA

Pain-induced negative affect is mediated via recruitment of the kappa opioid system in the nucleus accumbens – Jose Moron-Concepcion, Washington University in St. Louis

Central amygdala circuitry orchestrating the sensory and affective components of pain and itch – Rob Gereau, Washington University in St. Louis

11:30 AM to 1:30 PM

The Application of Stem Cell Models to Validate Rare and Common Variants Contributing to Schizophrenia and Autism: Chair, Michael Talkowski, Massachusetts General Hospital; Co-chair, Alexander Urban, Stanford

Transcriptional signatures of loss-of-function and reciprocal dosage of neurodevelopmental loci – Michael Talkowski, Massachusetts General Hospital

Functional evaluation of the neuronal impact of patient-specific aberrant NRXN1a splicing – Kristen Brennand, Mount Sinai School of Medicine

Functional interpretation of noncoding GWAS variants of schizophrenia in hiPSC model – Jubao Duan, University of Chicago

Analyzing the Molecular Effects of Large Neuropsychiatric CNVs with iPSC Based Neuronal Tissue Culture Models – Alexander Urban, Stanford

Transcriptional consequences of genomic variation in post-mortem schizophrenia brains – Douglas Ruderfer, Vanderbilt University

1:30 to 7:00 PM Break

7:00 to 8:00 PM

Plenary talk: Josh Gordon “Opportunities & challenges in psychiatric neuroscience”

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